A Novel Follicle-Cell-Dependent Dominant Female Sterile Allele,StarKojak, Alters Receptor Tyrosine Kinase Signaling inDrosophila

Receptor tyrosine kinase signaling in vascular development.

The formation and maintenance of the vascular circulatory system is of utmost importance during embryonic and postnatal life. The first organ system to develop is the cardiovascular network of endothelial cells that carry blood cells and metabolites throughout the embryo (1 , 2). Indeed, a functional vascular system is crucial for the rapid growth of postimplantation embryos. The vascular syste...

Casein Kinase 2 Dependent Phosphorylation of Neprilysin Regulates Receptor Tyrosine Kinase Signaling to Akt

Neprilysin (NEP) is a type II membrane metalloproteinase that cleaves physiologically active peptides at the cell surface thus regulating the local concentration of these peptides available for receptor binding and signal transduction. In addition, the cytoplasmic N-terminal domain of NEP interacts with the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) thereby regulating intr...

An effort to produce a homozygous dominant male-sterile cotton

Sprouty is a general inhibitor of receptor tyrosine kinase signaling.

Sprouty was originally identified as an inhibitor of Drosophila FGF receptor signaling during tracheal development. By following the capacity of ectopic Sprouty to abolish the pattern of activated MAP kinase in embryos, we show that Sprouty can inhibit other receptor tyrosine kinase (RTK) signaling pathways, namely the Heartless FGF receptor and the EGF receptor. Similarly, in wing imaginal dis...

Cell Signaling by Receptor Review Tyrosine Kinases